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Pickart and Margolinas 2018 review in Int J Mol Sci catalogs its regenerative and protective actions matrix remodeling, antioxidant and anti-inflammatory gene modulation, and wound-repair signaling but this is a review of largely preclinical and cell-based work (PMC6073405)

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Several DNA methylation-based epigenetic clocks have been established in the genome, such as Horvath, Hannum, PhenoAge, CheekAge, GrimAge, iCASDNAmAge, CultureAGE, and the scAge clock